产品名称:6-硫鸟嘌呤
英文名称:6-Thioguanine
CAS号 154-42-7
分子式 C5H5N5S
分子量167.19
属性
熔点 360°C
描述
别名 6-硫鸟嘌呤 ;6-硫代鸟嘌呤,2-氨基-6-巯基嘌呤,6-巯基鸟嘌呤,2-氨基嘌呤-6(1H)-硫酮 ;2-Amino-6-mercaptopurine
2-Amino-6-purinethiol
6-Mercaptoguanine
产品介绍 溶于NaOH 溶液。
用途 抗肿瘤。
生化机理
Description:
IC50 Value: 0.6 mM (ID50, 24 h exposure to HL-60 cell) [1]
6-TG belongs to the thiopurine family of drugs that also include mercaptopurineand azathioprine, which are examples of antimetabolites. It is a purine analogue of the nucleobase guanine.
in vitro: 6-TG was toxic to HL-60 cells (ID50 = 0.6 microM; 24-h exposure) while IFN-alpha (up to 1000 IU/ml) had minimal cytotoxic activity [1]. Paradoxically, inhibition of c-myc expression in the wild type HL-60 (HL-60/wt) cell, which is only weakly induced to differentiate by TG, was 5-fold more sensitive to the thiopurine (IC50 = 35 microM) [2].
in vivo: SOS did not occur in hypoxanthine-phosphoribosyl transferase-deficient C57Bl/6 mice, demonstrating that 6TG-SOS requires thioguanine nucleotides [3]. A higher fraction of the dose was recovered in urine as the parent thiopurine and the metabolites thiopurine riboside, thioxanthine, and thiouric acid after 6-TG treatment than after trans-AVTG treatment; cis-AVTP recovery was slightly less than that of 6-TG [4].
Clinical trial: 6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients. Phase 2
包装 T106639-1g in glass bottle
地址:上海一研生物科技有限公司
Shanghai yiyan bio-technology Co. Ltd.
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