英文名称Ack1
中文名称醋酸激酶1抗体
别 名Acetate kinase 1; Acetokinase 1; Activated CDC42 kinase 1; Activated Cdc42 associated kinase 1; Activated p21cdc42Hs kinase; Tyrosine kinase non receptor 2; Tyrosine kinase non-receptor protein 2; non-receptor protein tyrosine kinase ACK; ACK; TNK 2; Tnk2; ACK1; FLJ44758; FLJ45547; ACK 1; ACK-1; ACK1_HUMAN; Activated p21cdc42Hs kinase; FLJ44758; FLJ45547; Tyrosine kinase non receptor protein 2; p21cdc42Hs.
规格0.1ml 0.2ml
醋酸激酶1抗体研究领域肿瘤 免疫学 染色质和核信号 信号转导 激酶和磷酸酶 表观遗传学 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量119kDa
细胞定位细胞核 细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Ack1 N-t
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
醋酸激酶1抗体产品介绍background:
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq].
Function:
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
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一抗:
克隆类型: 多抗 单抗
产品类型: 标签抗体 磷酸化抗体 内参抗体 甲基化抗体
乙酰化抗体 药物与化合物抗 体植物抗体
研究领域: 肿瘤 心血管 细胞生物 免疫学 发育生物学 染色质和核信号
微生物学 细胞凋亡 信号转导 干细胞 神经生物学 生长因子和激素
糖尿病 内分泌病转 运蛋白 植物 细菌及病毒 转录调节因子
海洋生物 上皮细胞 趋化因子 结合蛋白 细胞表面分子 G蛋白偶联受体
胶原蛋白 糖蛋白 交换蛋白 细胞分化 血管内皮细胞 细胞类型标志物
内皮细胞 淋巴细胞 T-淋巴细胞 B-淋巴细胞 细胞粘附分子 肿瘤细胞生物标志物
骨髓细胞 细胞骨架 跨膜蛋白 细胞因子 自然杀伤细胞 树突状细胞标志物
脂蛋白 新陈代谢 锌指蛋白 通道蛋白 细胞周期蛋白 激酶和磷酸酶
昆虫 线粒体 环指蛋白 细胞自噬 细胞膜受体 药物及化合物
泛素 干扰素 G蛋白信号 细胞膜蛋白 Alzheimer's 表观遗传学
细胞外基质 合成与降解
标记一抗:
标记类型: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5
Cy7 PEPE-Cy3 PE-Cy5 PE-Cy5.5 PE-Cy7 APC Alexa Fluor 350 Alexa Fluor 488
Alexa Fluor 555 Alexa Fluor 594 Alexa Fluor 647
二抗:
克隆类型: 多抗 单抗
产品类型: 标签抗体 磷酸化抗体 内参抗体 甲基化抗体 乙酰化抗体 药物与化合物抗体 植物抗体
产品分类: 二抗 二 抗血清
标记二抗:
标记类型: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5
Cy7 PEPE-Cy3 PE-Cy5 PE-Cy5.5 PE-Cy7 APC Alexa Fluor 350 Alexa Fluor 488
Alexa Fluor 555 Alexa Fluor 594 Alexa Fluor 647
地址:上海一研生物科技有限公司
Shanghai yiyan bio-technology Co. Ltd.
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本公司的所有产品仅用于科学研究或者工业科研等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。