英文名称Acinus
中文名称Acinus抗体
别 名ACIN 1; ACIN1; ACINU_HUMAN; Acinus; ACN; Apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; DKFZp667N107; fSAP152; functional spliceosome-associated protein 152; KIAA0670.
规格0.1ml 0.2ml
Acinus抗体研究领域细胞生物 神经生物学 信号转导 细胞凋亡
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量148kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Acinus
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
Chromatin condensation and nuclear fragmentation (CCNF) are the hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by Caspase 3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated Acinus L (1341 amino acids), Acinus S (583 amino acids) and Acinus S' (614 amino acids)
Acinus抗体Function:
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
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一抗:
克隆类型: 多抗 单抗
产品类型: 标签抗体 磷酸化抗体 内参抗体 甲基化抗体
乙酰化抗体 药物与化合物抗 体植物抗体
研究领域: 肿瘤 心血管 细胞生物 免疫学 发育生物学 染色质和核信号
微生物学 细胞凋亡 信号转导 干细胞 神经生物学 生长因子和激素
糖尿病 内分泌病转 运蛋白 植物 细菌及病毒 转录调节因子
海洋生物 上皮细胞 趋化因子 结合蛋白 细胞表面分子 G蛋白偶联受体
胶原蛋白 糖蛋白 交换蛋白 细胞分化 血管内皮细胞 细胞类型标志物
内皮细胞 淋巴细胞 T-淋巴细胞 B-淋巴细胞 细胞粘附分子 肿瘤细胞生物标志物
骨髓细胞 细胞骨架 跨膜蛋白 细胞因子 自然杀伤细胞 树突状细胞标志物
脂蛋白 新陈代谢 锌指蛋白 通道蛋白 细胞周期蛋白 激酶和磷酸酶
昆虫 线粒体 环指蛋白 细胞自噬 细胞膜受体 药物及化合物
泛素 干扰素 G蛋白信号 细胞膜蛋白 Alzheimer's 表观遗传学
细胞外基质 合成与降解
标记一抗:
标记类型: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5
Cy7 PEPE-Cy3 PE-Cy5 PE-Cy5.5 PE-Cy7 APC Alexa Fluor 350 Alexa Fluor 488
Alexa Fluor 555 Alexa Fluor 594 Alexa Fluor 647
二抗:
克隆类型: 多抗 单抗
产品类型: 标签抗体 磷酸化抗体 内参抗体 甲基化抗体 乙酰化抗体 药物与化合物抗体 植物抗体
产品分类: 二抗 二 抗血清
标记二抗:
标记类型: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5
Cy7 PEPE-Cy3 PE-Cy5 PE-Cy5.5 PE-Cy7 APC Alexa Fluor 350 Alexa Fluor 488
Alexa Fluor 555 Alexa Fluor 594 Alexa Fluor 647
地址:上海一研生物科技有限公司
Shanghai yiyan bio-technology Co. Ltd.
电话:15021460884
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