产品名称：天然辣椒碱
CAS号 404-86-4
英文名称：Capsaicin
分子式 C18H27NO3
分子量 305.41

属性
存贮条件 储存温度 2-8°C
熔点 62-65°C
密度 1.0410
描述
别名 辣椒碱 ;天然辣椒素,(E)-N-(4-羟基-3-甲氧基苄基)-8-甲基-6-壬烯酰胺 ;E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
用途 辣椒的活性成分，辣椒素受体激动剂，神经毒素;激活感觉神经元。
生化机理
Description:
IC50 Value: 150 ?M (MTT assay in FaDu cells) [1]
Capsaicin is the active component of chili peppers, which are plantsbelonging to the genus Capsicum. Capsaicin, as a member of the vanilloidfamily, binds to a receptor called the vanilloid receptor subtype 1 (VR1). Capsaicin is able to kill prostate cancer and lung cancer cells by causing them to undergo apoptosis.
in vitro: Treatment of A172 cells withcapsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3. Interestingly, synergistic induction of morphological alternation was observed when A172 cells were treated with capsaicin [2]. After the addition of capsaicin, the levels of reactive oxygen species were reduced slightly in the earlier stage of treatment. Interestingly, an elevation of intracellular calcium ion concentration was detected in the MCF-7 cells [3].
in vivo: Intraperitoneal administration of CAP (10mg/kg body weigh
包装 C107691-20mg in glass bottle