产品名称：喜树碱
CAS号  7689-03-4 
英文名称：(S)-(+)-Camptothecin
分子式 C20H16N2O4
分子量 348.35

属性
存贮条件 贮存温度2-8℃
熔点 259-263°C
密度 1.5100
描述
别名 喜树碱 ;4-乙基-4-羟基-1H-吡喃[3'，4'：6，7]氮茚[1，2]喹啉-3，14(4H，12H)-二酮;4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
产品介绍 微溶于乙醇、氯仿，难溶于水。与酸不能生成稳定的盐，与氢氧化钠溶液加热反应可生成钠盐而溶于水。钠盐水溶液黄色澄明具蓝色荧光
用途 不可逆转地的结合到DNA拓扑异构酶I复合物上，影响细胞周期进程
生化机理
Camptothecin (CPT), a cytotoxic quinoline alkaloid, is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. It has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells.