英文名称ACVR1B
中文名称激活素A受体1B抗体
别    名Activin A receptor type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor; Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor type 1B; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR IB; ACTR-IB; ACTRIB; ACV1B_HUMAN; ACVR 1B; ACVR1B; ACVRLK 4; ACVRLK4; ALK 4; ALK-4; ALK4; Serine(threonine) protein kinase receptor R2; Serine/threonine-protein kinase receptor R2; SKR 2; SKR2.
激活素A受体1B抗体规格0.1ml  0.2ml  
研究领域细胞生物  免疫学  信号转导  干细胞  激酶和磷酸酶  结合蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
细胞定位细胞膜 
性    状Lyophilized or Liquid
浓    度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ACVR1B
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
激活素A受体1B抗体产品介绍background:
[FUNCTION]Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

一抗：

克隆类型：    多抗        单抗

产品类型：   标签抗体     磷酸化抗体     内参抗体     甲基化抗体      

                 乙酰化抗体   药物与化合物抗   体植物抗体

研究领域： 肿瘤            心血管        细胞生物       免疫学        发育生物学        染色质和核信号 

                微生物学      细胞凋亡     信号转导      干细胞         神经生物学        生长因子和激素

                海洋生物      上皮细胞     趋化因子     结合蛋白       细胞表面分子    G蛋白偶联受体

                胶原蛋白      糖蛋白       交换蛋白      细胞分化       血管内皮细胞    细胞类型标志物

                内皮细胞      淋巴细胞    T-淋巴细胞   B-淋巴细胞    细胞粘附分子    肿瘤细胞生物标志物

                骨髓细胞      细胞骨架      跨膜蛋白     细胞因子      自然杀伤细胞    树突状细胞标志物

                脂蛋白         新陈代谢     锌指蛋白      通道蛋白      细胞周期蛋白    激酶和磷酸酶

                昆虫            线粒体       环指蛋白       细胞自噬      细胞膜受体       药物及化合物 

                泛素           干扰素        G蛋白信号     细胞膜蛋白   Alzheimer's       表观遗传学 

                细胞外基质    合成与降解

标记一抗：

标记类型：  HRP                   Biotin                 Gold               RBITC     AP        FITC       Cy3       Cy5      Cy5.5  

                Cy7                    PEPE-Cy3            PE-Cy5            PE-Cy5.5  PE-Cy7 APC        Alexa Fluor 350     Alexa Fluor 488

                Alexa Fluor 555    Alexa Fluor 594    Alexa Fluor 647

二抗：

克隆类型：  多抗        单抗

产品类型：  标签抗体   磷酸化抗体    内参抗体     甲基化抗体     乙酰化抗体      药物与化合物抗体     植物抗体

产品分类：  二抗         二 抗血清

标记二抗：

标记类型：  HRP                   Biotin                 Gold               RBITC     AP        FITC       Cy3       Cy5      Cy5.5  

                Cy7                    PEPE-Cy3            PE-Cy5            PE-Cy5.5  PE-Cy7 APC        Alexa Fluor 350     Alexa Fluor 488

                Alexa Fluor 555    Alexa Fluor 594    Alexa Fluor 647